{"id":53541,"date":"2019-10-30T10:46:55","date_gmt":"2019-10-30T05:16:55","guid":{"rendered":"https:\/\/blogadmin.forumias.com\/?page_id=53541"},"modified":"2019-10-30T10:47:03","modified_gmt":"2019-10-30T05:17:03","slug":"answered-what-do-you-understand-by-the-term-genome-sequencing-discuss-its-importance-and-associated-challenges-wrt-genome-sequencing-in-india","status":"publish","type":"page","link":"https:\/\/forumias.com\/blog\/answered-what-do-you-understand-by-the-term-genome-sequencing-discuss-its-importance-and-associated-challenges-wrt-genome-sequencing-in-india\/","title":{"rendered":"[Answered] What do you understand by the term \u2018genome sequencing\u2019? Discuss its Importance and associated challenges wrt genome sequencing in India."},"content":{"rendered":"\n
Demand of the question<\/strong>
Introduction. <\/strong>What is genome sequencing?
Body. <\/strong>Discuss its significance and related challenges wrt genome sequencing.
Conclusion. <\/strong>Way forward. <\/td><\/tr><\/tbody><\/table>\n\n\n\n

Genome sequencing is process of figuring out the order of DNA nucleotides, or bases, in a genome that make up an organism’s DNA. The human genome is made up of over 3 billion of these genetic letters. <\/p>\n\n\n\n

Significance of human genome\nsequencing:<\/strong><\/p>\n\n\n\n

  1. Determining gene-disease link: <\/strong>Human genome sequencing is important\nto establish link between certain disease and the unique genetic make-up of\neach individual. Genomic sequencing can provide information on genetic variants\nthat can lead to disease or can increase the risk of disease development, even\nin asymptomatic people.<\/li>
  2. Better understanding of cancer: <\/strong>While genes may render some\ninsensitive to certain drugs, genome sequencing has shown that cancer too can\nbe understood from the viewpoint of genetics, rather than being seen as a\ndisease of certain organs.<\/li>
  3. Mapping population diversity:<\/strong> Participants of genome-sample\ncollections represent diversity of the country\u2019s population.<\/li>
  4. Better diagnostic and treatment: <\/strong>The primary purpose of sequencing\none\u2019s genome is to obtain information of medical value for future care. For\npeople experiencing a health-impacting condition, DNA sequencing can provide a\nprecise diagnosis which might affect the medical management of symptoms, or\nprovide treatment options.<\/li>
  5. Drug efficacy: <\/strong>Another advantage of genome\nsequencing is that information regarding drug efficacy or adverse effects of\ndrug use can be obtained. The relationship between drugs and the genome is\ncalled pharmacogenomics.<\/li><\/ol>\n\n\n\n

    Challenges and issues related to\ngenome sequencing:<\/strong><\/p>\n\n\n\n

    1. How accurately and reliably genome\nsequencing measures genome variants is a big challenge. <\/li>
    2. The role of most of the genes in the\nhuman genome is still unknown or incompletely understood. Therefore, a lot of\nthe \u201cinformation\u201d found in a human genome sequence is unusable at present.<\/li>
    3. Most physicians are not trained in\nhow to interpret genomic data.<\/li>
    4. An individual\u2019s genome may contain\ninformation that they DON\u2019T want to know. For example, a patient has genome\nsequencing performed to determine the most effective treatment plan for high\ncholesterol. In the process, researchers discover an unrelated allele that\nassures a terminal disease with no effective treatment.<\/li>
    5. The volume of information contained\nin a genome sequence is vast. Policies and security measures to maintain the\nprivacy and safety of this information are still new.<\/li>
    6. The introduction of whole genome\nsequencing may have ethical implications. Genetic testing has potential\ndownsides such as genetic discrimination, loss of anonymity, and psychological\nimpacts.<\/li><\/ol>\n\n\n\n

      Given the benefits of genome sequencing, it will help in better understanding of human body and processes and will help in treating earlier untreatable diseases. Although there are some issues and challenges but these can be handled and resolved. CSIR (Council of Scientific and Industrial Research) plans to undertake genome sequencing to determine unique genetic traits, susceptibility (and resilience) to disease which will help Indian citizens.<\/p>\n","protected":false},"excerpt":{"rendered":"

      Demand of the question Introduction. What is genome sequencing? Body. Discuss its significance and related challenges wrt genome sequencing. Conclusion. Way forward. Genome sequencing is process of figuring out the order of DNA nucleotides, or bases, in a genome that make up an organism’s DNA. The human genome is made up of over 3 billion… Continue reading [Answered] What do you understand by the term \u2018genome sequencing\u2019? Discuss its Importance and associated challenges wrt genome sequencing in India.<\/span><\/a><\/p>\n","protected":false},"author":61,"featured_media":49132,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-53541","page","type-page","status-publish","has-post-thumbnail","hentry","entry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/pages\/53541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=53541"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/pages\/53541\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media\/49132"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=53541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}