{"id":1909,"date":"2017-06-17T17:33:13","date_gmt":"2017-06-17T17:33:13","guid":{"rendered":"http:\/\/blog.forumias.com\/?p=1909"},"modified":"2021-04-26T16:54:40","modified_gmt":"2021-04-26T11:24:40","slug":"cdsco-has-registered-the-oral-pellet-form-for-easy-use","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/cdsco-has-registered-the-oral-pellet-form-for-easy-use\/","title":{"rendered":"CDSCO has registered the oral pellet form for easy use"},"content":{"rendered":"<p><strong><u>Understanding the context<\/u><\/strong><\/p>\n<ul>\n<li>The\u00a0 CDSCO Central Drugs Standard Control Organization registered the child-friendly HIV drug in oral pellet form.<\/li>\n<li>This has opened up crucial supplies from Cipla Pharmaceuticals, a dominant player in the HIV segment<\/li>\n<li>Cipla developed a different formulation\u00a0of the child-friendly HIV drug Lopinavir and Ritonavir.<\/li>\n<li>Those were pellets of lopinavir and ritonavir, packaged as micro-tablets inside a capsule.<\/li>\n<li>The need for new formulation was quality issues with the syrup made earlier by Cipla.<\/li>\n<li>The National Aids Control Programme (NACO) had been facing problem to procure quality assured pediatric formulations of the drug after Liponavir syrup ran out of stock.<\/li>\n<\/ul>\n<p><strong><u>Crisis<\/u><\/strong><\/p>\n<ul>\n<li>NACO completely ran out of syrup comprising the drugs lopinavir and ritonavir which is given to children up to the age of 3 with HIV or AIDS.<\/li>\n<li>HIV and AIDS patients need to take their antiretroviral medicines at fixed times every day.<\/li>\n<li>Missing or skipping a dose escalates the chances of drug resistance with patients failing to respond to the drugs.<\/li>\n<li>Faced with a crisis, the Health Ministry had instructed State AIDS Control Societies (SACS) to purchase the medicine from local markets.<\/li>\n<li>However, since the syrup had gone out of production, they were not available in retail markets.<\/li>\n<\/ul>\n<p><strong><u>What led to the crisis?<\/u><\/strong><\/p>\n<ul>\n<li>The Lopinavir syrup which is a child-friendly HIV drug ran out of stock<\/li>\n<li>This happened as Cipla, the sole manufacturer of the drug stopped the production.<\/li>\n<li>Non-payment from the Health Ministry was the issue behind stopping the production of the drug.<\/li>\n<\/ul>\n<p><strong><u>Timeline<\/u><\/strong><\/p>\n<ul>\n<li><strong>2014<\/strong>: NACO got a stock of lopinavir\/ritonavir syrup from Cipla which is the sole maker of the drug in the country.<\/li>\n<li><strong>2015<\/strong>: Cipla stops the manufacture of the syrup and switches over to pellets of the same formulation.<\/li>\n<li><strong>October 2016<\/strong>: NACO issued tenders for syrup but no company bid.<\/li>\n<li><strong>January 2017<\/strong>: NACO issued tenders for the syrup again. The activists working with HIV patients informed them that Cipla has stopped manufacturing the drug.<\/li>\n<li><strong>January 2017<\/strong>: The stock of syrup acquired from Cipla in 2014 ran out.<\/li>\n<li><strong>End of February 2017<\/strong>: NACO requests\u00a0McNeil &amp; Argus Pharmaceuticals to manufacture the syrup on an emergency basis.<\/li>\n<li><strong>March 2017<\/strong>: struggling with the shortage of life-saving drugs, Children living with HIV (CLHIV) wrote a letter to Prime Minister\u00a0urging him to address the issue.<\/li>\n<\/ul>\n<p><strong><u>The significance of the issue<\/u><\/strong><strong>:<\/strong><\/p>\n<ul>\n<li>Children are some of the most vulnerable HIV patients.<\/li>\n<li>Lack of child-friendly, quality-assured HIV drugs is one of the major reasons behind the treatment gap between adults and children<\/li>\n<li>The registration of pellets is a positive step towards this issue.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Understanding the context The\u00a0 CDSCO Central Drugs Standard Control Organization registered the child-friendly HIV drug in oral pellet form. This has opened up crucial supplies from Cipla Pharmaceuticals, a dominant player in the HIV segment Cipla developed a different formulation\u00a0of the child-friendly HIV drug Lopinavir and Ritonavir. Those were pellets of lopinavir and ritonavir, packaged&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/cdsco-has-registered-the-oral-pellet-form-for-easy-use\/\">Continue reading <span class=\"screen-reader-text\">CDSCO has registered the oral pellet form for easy use<\/span><\/a><\/p>\n","protected":false},"author":61,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[31],"tags":[],"class_list":["post-1909","post","type-post","status-publish","format-standard","hentry","category-science-technology","entry"],"jetpack_featured_media_url":"","views":{"total":0,"cached_at":"","cached_date":1704848252},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/1909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=1909"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/1909\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=1909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=1909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=1909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}