{"id":228480,"date":"2023-02-24T20:40:48","date_gmt":"2023-02-24T15:10:48","guid":{"rendered":"https:\/\/blog.forumias.com\/?p=228480"},"modified":"2023-02-24T20:40:48","modified_gmt":"2023-02-24T15:10:48","slug":"new-delivery-mechanisms-for-genetic-therapy-will-do-us-good","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/new-delivery-mechanisms-for-genetic-therapy-will-do-us-good\/","title":{"rendered":"New delivery mechanisms for genetic therapy will do us good"},"content":{"rendered":"\n

Source<\/strong>– The post is based on the article \u201cNew delivery mechanisms for genetic therapy will do us good\u201d <\/strong>published in the mint <\/strong>on 24th February 2023<\/strong>.<\/p>\n

Syllabus: <\/strong>GS3- Awareness in the field of biotechnology<\/p>\n

Relevance:<\/strong> Regulatory system of drugs in India<\/p>\n

News- <\/strong>A biotech company called Aera Therapeutics has unveiled a type of protein nanoparticle that can be used to deliver all sorts of genetic medicines around the body.<\/p>\n

What are the challenges associated with present genetic therapies?<\/strong><\/h2>\n

The presently available genetic therapy technologies<\/strong> can only fix the genome in reachable parts of the body. Its reach <\/strong>is very limited. The liver, eyes and blood are the main places where cures might be possible.<\/p>\n

These technologies largely rely on viral vectors and lipid nanoparticles<\/strong>. But they can only efficiently deliver to certain Zip codes. Lipid nanoparticles\u2019 routes are largely limited to the liver and eyes.<\/p>\n

These have other limitations, for example how much cargo they can hold. Some genes for fixing the diseases are too big to fit inside a virus. It can be tough to squeeze the instructions<\/strong> for making Crispr tools into a usable lipid nanoparticle.<\/p>\n

What are some facts associated with the new protein nanoparticle unveiled by Aera?<\/strong><\/h2>\n

It is capitalizing on a recent discovery about a class of human proteins<\/strong> that are relics of viruses that infected humans ages ago.<\/p>\n

One of these proteins assembled into a protein shell of a virus particle <\/strong>that stored the RNA needed for making more copies of itself.<\/p>\n

Massachusetts Institute of Technology scientist Feng Zhang saw in the discovery an opportunity to exploit the system to deliver genetic material<\/strong> of his choice.<\/p>\n

His lab experimented on the human genome for other proteins that assemble into protective shells <\/strong>and probed whether they were capable of transferring RNA<\/strong>.<\/p>\n

In 2021, they showed that one of the proteins, called PEG10<\/strong> could be repurposed to deliver gene-editing tool<\/strong>s. That work became the foundation for Aera.<\/p>\n

So far, around 50 of these self-assembling proteins<\/strong> have been found. The protective shells these proteins form come in a range of sizes. It means that some might be better suited for<\/p>\n

slipping across the blood-brain barrier.<\/p>\n

They are also, in theory, adaptable<\/strong>. Scientists have gotten very good at engineering proteins <\/strong>to do specific jobs. So, it is reasonable to think Aera researchers could engineer the capsids to travel to specific organs or tissues.<\/p>\n","protected":false},"excerpt":{"rendered":"

Source– The post is based on the article \u201cNew delivery mechanisms for genetic therapy will do us good\u201d published in the mint on 24th February 2023. Syllabus: GS3- Awareness in the field of biotechnology Relevance: Regulatory system of drugs in India News- A biotech company called Aera Therapeutics has unveiled a type of protein nanoparticle… Continue reading New delivery mechanisms for genetic therapy will do us good<\/span><\/a><\/p>\n","protected":false},"author":10320,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1230,9],"tags":[216,11126],"class_list":["post-228480","post","type-post","status-publish","format-standard","hentry","category-9-pm-daily-articles","category-public","tag-gs-paper-3","tag-the-mint","entry"],"jetpack_featured_media_url":"","views":{"total":0,"cached_at":"","cached_date":1704740597},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/228480","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10320"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=228480"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/228480\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=228480"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=228480"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=228480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}