{"id":253553,"date":"2023-07-26T20:37:29","date_gmt":"2023-07-26T15:07:29","guid":{"rendered":"https:\/\/blog.forumias.com\/?p=253553"},"modified":"2023-08-31T10:31:46","modified_gmt":"2023-08-31T05:01:46","slug":"welcome-happening-robust-institutional-mechanisms-must-be-in-place-for-human-challenge-studies","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/welcome-happening-robust-institutional-mechanisms-must-be-in-place-for-human-challenge-studies\/","title":{"rendered":"Welcome happening: Robust institutional mechanisms must be in place for human challenge studies"},"content":{"rendered":"\n<p><strong>Source:<\/strong> The post is based on the article \u201c<strong>Welcome happening: Robust institutional mechanisms must be in place for human challenge studies<\/strong>\u201d published in \u201cThe Hindu\u201d on 26th July 2023.<\/p>\n<p><strong>Syllabus:<\/strong> GS2- Issues relating to development and management of Social Sector\/Services relating to Health, Education &amp; GS4- compassion towards the weaker-sections.<\/p>\n<p><strong>News:<\/strong> The author discusses the need for strong institutional mechanisms and ethical considerations before conducting human challenge studies (CHIS) in India.<\/p>\n<h2><strong>What are Human Challenge Studies (CHIS)?<\/strong><\/h2>\n<p><strong>Definition of CHIS:<\/strong> Human Challenge Studies (CHIS) involve intentionally exposing healthy volunteers to disease-causing microbes in a controlled environment for research purposes.<\/p>\n<p><strong>Purpose of CHIS:<\/strong> CHIS aims to study various facets of infections and diseases, test medical interventions, and accelerate vaccine development.<\/p>\n<h2><strong>What are the benefits of CHIS?<\/strong><\/h2>\n<p><strong>Faster Vaccine Development:<\/strong> CHIS can accelerate vaccine development by providing critical data on immune responses and safety, reducing the need for large phase-3 trials.<\/p>\n<p><strong>Understanding Infections:<\/strong> CHIS helps researchers gain valuable insights into the various facets of infections and diseases, aiding in the development of effective treatments.<\/p>\n<p><strong>Controlled Environment<\/strong>: CHIS allows for the study of diseases in a controlled and monitored setting, minimizing risks to the wider population.<\/p>\n<p><strong>Cost-Effectiveness:<\/strong> CHIS can potentially reduce the cost and time required for vaccine development.<\/p>\n<h2><strong>What are the challenges of CHIS?<\/strong><\/h2>\n<p><strong>Ethical Concerns:<\/strong> CHIS raises ethical issues related to the intentional exposure of healthy volunteers to disease-causing microbes.<\/p>\n<p><strong>Potential for Exploitation:<\/strong> Monetary incentives involved in CHIS may lead to the exploitation of volunteers.<\/p>\n<p><strong>Robust Institutional Mechanisms:<\/strong> Conducting CHIS requires well-trained personnel and strong institutional structures.<\/p>\n<p><strong>Previous Ethical Violations:<\/strong> Instances like the HPV vaccine trial in Andhra Pradesh (2010) highlight the importance of stringent oversight.<\/p>\n<p><strong>Limited Medical Intervention:<\/strong> CHIS may be unsuitable for studying novel diseases with limited medical interventions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Source: The post is based on the article \u201cWelcome happening: Robust institutional mechanisms must be in place for human challenge studies\u201d published in \u201cThe Hindu\u201d on 26th July 2023. Syllabus: GS2- Issues relating to development and management of Social Sector\/Services relating to Health, Education &amp; GS4- compassion towards the weaker-sections. News: The author discusses the&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/welcome-happening-robust-institutional-mechanisms-must-be-in-place-for-human-challenge-studies\/\">Continue reading <span class=\"screen-reader-text\">Welcome happening: Robust institutional mechanisms must be in place for human challenge studies<\/span><\/a><\/p>\n","protected":false},"author":10320,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1230,9],"tags":[212,8131,10498],"class_list":["post-253553","post","type-post","status-publish","format-standard","hentry","category-9-pm-daily-articles","category-public","tag-gs-paper-2","tag-social-issues","tag-the-hindu","entry"],"jetpack_featured_media_url":"","views":{"total":0,"cached_at":"","cached_date":1702142102},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/253553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10320"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=253553"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/253553\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=253553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=253553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=253553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}