{"id":27665,"date":"2018-10-23T15:26:23","date_gmt":"2018-10-23T09:56:23","guid":{"rendered":"https:\/\/blog.forumias.com\/?p=27665"},"modified":"2018-10-23T15:26:23","modified_gmt":"2018-10-23T09:56:23","slug":"the-bedaquiline-boost","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/the-bedaquiline-boost\/","title":{"rendered":"The bedaquiline boost"},"content":{"rendered":"<p><a href=\"https:\/\/www.thehindu.com\/opinion\/op-ed\/the-bedaquiline-boost\/article24857412.ece\">The bedaquiline boost<\/a><\/p>\n<p><strong><u>News<\/u><\/strong>:<\/p>\n<ol>\n<li>WHO to replace all injectable with oral drugs \u201cBedaquiline\u201d to treat MDR-TB patients.<\/li>\n<\/ol>\n<p><strong><u>Important Facts:<\/u><\/strong><\/p>\n<p>2. WHO has recommended to change in method to treat MDR-TB patient by replacing all injectable with oral Bedaquiline.<\/p>\n<p>3. MDR-TB is resistant to at least two of the first-line drugs.<\/p>\n<p>4. Why treating MDR-TB using injectable drugs was objectionable.<\/p>\n<ul>\n<li>Patient discontinued treatment due to adverse effect of injectable drugs.<\/li>\n<li>Success rate for MDR-TB was only 54% for patient started treatment in 2014.<\/li>\n<\/ul>\n<p>5 WHO has informed member states to take immediate steps to ensure effective treatment to MDR-TB patients in accordance with new guidelines.<\/p>\n<p>6. According to WHO recommendation, Bedaquiline will be provided to MDR-TB patient as a last resort because clinical trial (Phase III) is still not completed for the new drugs.<\/p>\n<p>7. In Phase IIb trials, the drug was found to have cardio-toxicity and also caused few deaths.<\/p>\n<p>8. India had an estimated 84,000 new MDR\/rifampicin-resistant-TB cases in 2016.<\/p>\n<p>9. According to first ever drug testing carried out in India in 2014-16, 6.19 % were found to be multi-drug resistant.<\/p>\n<p>10. Johnson and Johnson company has made an offer to drug at $400 to India.<\/p>\n<p>11. India has been getting bedaquiline drug courses (11,000 so far) for free under the conditional access programme of USAID.<\/p>\n<p>12. South Africa was the first country to scale up access to bedaquiline.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The bedaquiline boost News: WHO to replace all injectable with oral drugs \u201cBedaquiline\u201d to treat MDR-TB patients. Important Facts: 2. WHO has recommended to change in method to treat MDR-TB patient by replacing all injectable with oral Bedaquiline. 3. MDR-TB is resistant to at least two of the first-line drugs. 4. Why treating MDR-TB using&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/the-bedaquiline-boost\/\">Continue reading <span class=\"screen-reader-text\">The bedaquiline boost<\/span><\/a><\/p>\n","protected":false},"author":61,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[555],"tags":[],"class_list":["post-27665","post","type-post","status-publish","format-standard","hentry","category-test-1","entry"],"jetpack_featured_media_url":"","views":{"total":0,"cached_at":"","cached_date":1704769341},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/27665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=27665"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/27665\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=27665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=27665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=27665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}