{"id":28650,"date":"2018-10-24T14:11:42","date_gmt":"2018-10-24T08:41:42","guid":{"rendered":"https:\/\/blog.forumias.com\/?p=28650"},"modified":"2018-10-24T14:11:42","modified_gmt":"2018-10-24T08:41:42","slug":"a-tb-vaccine-for-diabetics","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/a-tb-vaccine-for-diabetics\/","title":{"rendered":"A TB vaccine for diabetics?"},"content":{"rendered":"<p><a href=\"http:\/\/www.thehindu.com\/opinion\/op-ed\/a-tb-vaccine-for-diabetics\/article24255660.ece\">A TB vaccine for diabetics?<\/a><\/p>\n<p><strong><u>News:<\/u><\/strong><\/p>\n<ol>\n<li>According to a study published in <em>npj Vaccines<\/em>, tuberculosis vaccine called BCG(Bacillus Calmette-Guerin) might lower blood sugar in diabetes patients over a five to eight year period.<\/li>\n<\/ol>\n<p><strong><u>Important facts:<\/u><\/strong><\/p>\n<p><strong><u>2. Case Study<\/u><\/strong><\/p>\n<ul>\n<li>In the study, \u201cLong-term reduction in hyperglycemia in advanced type 1 diabeties\u201d, patients received BCG vaccine. Three year later, other patients received the same treatment.<\/li>\n<li>The trial investigators, led by immunologist Denise L. Faustman from Massachusetts General Hospital in the U.S.\u00a0 The findings of this study are given below:<\/li>\n<\/ul>\n<p>3. The study found a sustained drop in a marker for high-blood sugar called HbA1c.<\/p>\n<p>4. None of the patients experienced hypoglycaemia or dangerously low blood sugar, a potentially life-threatening side-effect in patients taking insulin.<\/p>\n<p>5. The study promises a safe and inexpensive treatment for type-I diabetics, if replicated in large clinical trials.<\/p>\n<p>6. Even though the BCG vaccine doesnot work very well against childhood TB, it protects against leprosy, sepsis among babies and leishmaniasis.<\/p>\n<p>7. It is also the first approved immunotheraphy against bladder cancer.<\/p>\n<p>8. Although BCG seemed to have regenerated the pancreas in the phase 1 trial, the Faustaman team found little improvement in their patients\u2019 HbA1C levels.<\/p>\n<p>9. In the phase I trial, Faustaman team gave the BCG vaccine to three patients, finds that the patients produced more pancreatic insulin and had more of a type of immune cell called Regulatory T cells(Tregs), which protect against autoimmune diseases.<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"638\"><strong><u>Type-1 diabetes:<\/u><\/strong><\/p>\n<ul>\n<li>\u00a0Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic condition in which pancreas produces little or no insulin.<\/li>\n<li>\u00a0 Insulin is a hormone needed to allow sugar (glucose) to enter cells to produce energy.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>10. BCG increased the numbers of Tregs.<\/p>\n<p>11. although, Tregs help type-1 patients a little, it switch to glycolysis which extracts more sugar from the bloodstream, which seems to be behind the improvement in HbA1c.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A TB vaccine for diabetics? News: According to a study published in npj Vaccines, tuberculosis vaccine called BCG(Bacillus Calmette-Guerin) might lower blood sugar in diabetes patients over a five to eight year period. Important facts: 2. Case Study In the study, \u201cLong-term reduction in hyperglycemia in advanced type 1 diabeties\u201d, patients received BCG vaccine. Three&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/a-tb-vaccine-for-diabetics\/\">Continue reading <span class=\"screen-reader-text\">A TB vaccine for diabetics?<\/span><\/a><\/p>\n","protected":false},"author":61,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[555],"tags":[],"class_list":["post-28650","post","type-post","status-publish","format-standard","hentry","category-test-1","entry"],"jetpack_featured_media_url":"","views":{"total":0,"cached_at":"","cached_date":1702920245},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/28650","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=28650"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/28650\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=28650"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=28650"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=28650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}