![\"Toxic](\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2024\/11\/Toxic-Epidermal-Necrolysis.png?resize=633%2C422&ssl=1\")
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Source: This post on Toxic epidermal necrolysis (TEN)<\/strong> has been created based on the article “Australian-German research finds world first cure for deadly skin disease” <\/a>published in Assam Tribune on 13th November 2024.<\/p>\n Researchers from Australia and Germany have achieved a groundbreaking medical milestone, developing the first cure for toxic epidermal necrolysis (TEN).<\/p>\n 1. Experts identified that the JAK-STAT signalling pathway is a cellular process integral to immune response, cell death, and tumour formation and is hyperactivated in TEN patients.<\/p>\n 2. By employing JAK inhibitors, a drug class typically used to treat inflammatory diseases, researchers successfully treated seven patients with TEN.<\/p>\n 1. Toxic epidermal necrolysis (TEN) is a severe, life-threatening skin reaction characterized by widespread skin necrosis and detachment of the epidermis.<\/p>\n 2. Cause:<\/strong> Most commonly caused by reactions to medications, including antibiotics (e.g., sulfonamides), anticonvulsants, nonsteroidal anti-inflammatory drugs (NSAIDs), and allopurinol. Less frequently, infections or other factors may trigger TEN.<\/p>\n 3. Symptoms:<\/strong> High fever and flu-like symptoms often precede skin lesions, Rapid development of red, painful skin areas that evolve into large blisters and peeling, extensive skin detachment, often covering more than 30% of body surface area and mucous membrane involvement, such as in the mouth, eyes, and genitals.<\/p>\n 4. Diagnosis:<\/strong> Based on clinical appearance and patient history of recent medication use. Skin biopsy can confirm the diagnosis, showing characteristic necrosis of the epidermis.<\/p>\n 5. Complications:<\/strong><\/p>\n i) Severe fluid loss and electrolyte imbalance due to extensive skin loss.<\/p>\n ii) \u00a0Increased risk of infections (especially sepsis) due to loss of the skin barrier.<\/p>\n iii) Long-term complications can include scarring, pigmentation changes, and eye damage (such as blindness).<\/p>\n 6. Treatment:<\/strong> \u00a0Immediate hospitalization, often in an intensive care unit or burn unit, Discontinuation of the suspected drug(s) and supportive care for skin lesions, including fluid replacement, pain management, and wound care.<\/p>\n Immunosuppressive therapies (e.g., intravenous immunoglobulins or corticosteroids) may be considered, though their efficacy is debated.<\/p>\n 7. Prognosis:<\/strong> The mortality rate for TEN can be high, especially if diagnosis and treatment are delayed. The SCORTEN score is often used to predict prognosis based on several clinical factors.<\/p>\n 8. Prevention:<\/strong> Genetic testing (such as for HLA-B*1502 allele) may help prevent TEN in susceptible populations when prescribing certain drugs (e.g., carbamazepine in Asian populations).<\/p>\n UPSC Syllabus: Science and technology\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" Source: This post on Toxic epidermal necrolysis (TEN) has been created based on the article “Australian-German research finds world first cure for deadly skin disease” published in Assam Tribune on 13th November 2024. Why in news? Researchers from Australia and Germany have achieved a groundbreaking medical milestone, developing the first cure for toxic epidermal necrolysis… Continue reading Toxic epidermal necrolysis (TEN)<\/span><\/a><\/p>\n","protected":false},"author":10366,"featured_media":316150,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1566,1738],"tags":[11872,12050],"class_list":["post-316012","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-daily-factly-articles","category-science-and-technology-daily-factly-articles","tag-9pm-daily-factly","tag-assam-tribune","entry"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2024\/11\/Toxic-Epidermal-Necrolysis.png?fit=1280%2C853&ssl=1","views":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/316012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10366"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=316012"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/316012\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media\/316150"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=316012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=316012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=316012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Why in news?<\/h2>\n
About the cure<\/h2>\n
About toxic epidermal necrolysis (TEN)<\/h2>\n