{"id":32377,"date":"2018-10-29T13:47:58","date_gmt":"2018-10-29T08:17:58","guid":{"rendered":"https:\/\/blog.forumias.com\/?p=32377"},"modified":"2018-10-29T13:47:58","modified_gmt":"2018-10-29T08:17:58","slug":"alternative-drugs-for-mild-infection-the-way","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/alternative-drugs-for-mild-infection-the-way\/","title":{"rendered":"Alternative drugs for mild infection the way\u00a0"},"content":{"rendered":"<p><a href=\"http:\/\/www.thehindu.com\/sci-tech\/health\/alternative-drugs-for-mild-infection-the-way\/article22347419.ece\"><strong>Alternative drugs for mild infection the way<\/strong><\/a><strong>\u00a0<\/strong><\/p>\n<p><strong>Context<\/strong><\/p>\n<p>Drug resistance<\/p>\n<p><strong>News<\/strong><\/p>\n<p>Developing alternatives to antibiotics for small infections could prevent bacteria from developing drug-resistance and help humans win the battle against superbugs, scientists say<\/p>\n<p><strong>Backdrop<\/strong><\/p>\n<ul>\n<li>It has been widely reported that bacteria will evolve to render antibiotics mostly ineffective by mid-century, and current strategies to make up for the projected shortfalls have not worked.<\/li>\n<li>Doctors are often quick to prescribe strong antibiotics for mild infections, helping bacteria evolve resistance to even the most potent drugs<\/li>\n<\/ul>\n<p><strong>Focusing on extreme infections<\/strong><\/p>\n<p>One possible problem is that drug development strategies have focused on replacing antibiotics in extreme infections, such as sepsis, where every minute without an effective drug increases the risk of death<\/p>\n<p><strong>Need of the hour: Focusing on smaller infections<\/strong><\/p>\n<p>However, the evolutionary process that brings forth antibiotic resistance does not happen nearly as often in those big infections as it does in the multitude of small ones like sinusitis, tonsillitis, bronchitis, and bladder infections, according to researchers from the Georgia Institute of Technology in the U.S.<\/p>\n<p><strong>Prescriptions to smaller ailments a major threat<\/strong><\/p>\n<ul>\n<li>Antibiotic prescriptions against those smaller ailments account for about 90 percent of antibiotic use, and so are likely to be the major driver of resistance evolution<\/li>\n<li>Bacteria that survive these many small battles against antibiotics grow in strength and numbers to become formidable armies in big infections, like those that strike after surgery\n<ul>\n<li>For example, <strong>E coli<\/strong> is widespread in the human gut. While some strains secrete enzymes that thwart antibiotics, others do not<\/li>\n<li>A broad-spectrum antibiotic can kill off more of the vulnerable, less dangerous bacteria, leaving the more dangerous and robust bacteria to propagate<\/li>\n<li>Often, superbugs have made their way into hospitals in someone\u2019s intestines, where they had evolved high resistance through years of occasional treatment with antibiotics for small infections. Then bacteria have infected patients with weak immune systems<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>Different approach<\/strong><\/p>\n<p>Furious infections have ensued, essentially invulnerable to antibiotics, followed by sepsis and death. The researchers proposed a different approach. Developing non-antibiotic therapies for strep throat, bladder infections, and bronchitis could prove easier, thus encouraging pharmaceutical research<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alternative drugs for mild infection the way\u00a0 Context Drug resistance News Developing alternatives to antibiotics for small infections could prevent bacteria from developing drug-resistance and help humans win the battle against superbugs, scientists say Backdrop It has been widely reported that bacteria will evolve to render antibiotics mostly ineffective by mid-century, and current strategies to&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/alternative-drugs-for-mild-infection-the-way\/\">Continue reading <span class=\"screen-reader-text\">Alternative drugs for mild infection the way\u00a0<\/span><\/a><\/p>\n","protected":false},"author":61,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[555],"tags":[],"class_list":["post-32377","post","type-post","status-publish","format-standard","hentry","category-test-1","entry"],"jetpack_featured_media_url":"","views":{"total":0,"cached_at":"","cached_date":1704937737},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/32377","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=32377"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/32377\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=32377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=32377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=32377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}