{"id":338300,"date":"2025-05-27T16:08:08","date_gmt":"2025-05-27T10:38:08","guid":{"rendered":"https:\/\/forumias.com\/blog\/?p=338300"},"modified":"2025-05-28T19:40:16","modified_gmt":"2025-05-28T14:10:16","slug":"arhgap36-gene","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/arhgap36-gene\/","title":{"rendered":"ARHGAP36 gene"},"content":{"rendered":"<p><strong>News:<\/strong> Two independent studies by Stanford University (USA) and Kyushu University (Japan) have identified the ARHGAP36 gene as the reason behind the orange coat colour in ginger cats. The discovery ends a century-long mystery in feline genetics. <strong>ARHGAP36 gene<\/strong><\/p>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\" wp-image-338638 aligncenter\" src=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/05\/ARHGAP36-gene.png?resize=476%2C316&#038;ssl=1\" alt=\"ARHGAP36 gene\" width=\"476\" height=\"316\" srcset=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/05\/ARHGAP36-gene.png?resize=300%2C199&amp;ssl=1 300w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/05\/ARHGAP36-gene.png?resize=1024%2C680&amp;ssl=1 1024w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/05\/ARHGAP36-gene.png?resize=768%2C510&amp;ssl=1 768w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/05\/ARHGAP36-gene.png?w=1280&amp;ssl=1 1280w\" sizes=\"auto, (max-width: 476px) 100vw, 476px\" \/><\/p>\n<h2><strong>About ARHGAP36 gene\u00a0<\/strong><\/h2>\n<ul>\n<li>The <strong data-start=\"4\" data-end=\"21\">ARHGAP36 gene<\/strong> (Rho GTPase Activating Protein 36) encodes a <strong data-start=\"67\" data-end=\"89\">regulatory protein<\/strong> that belongs to the <strong data-start=\"110\" data-end=\"149\">Rho GTPase-activating protein (GAP)<\/strong> family.<\/li>\n<li>In orange cats, <strong>higher levels of RNA from the Arhgap36 gene<\/strong> are expressed in pigment cells.<\/li>\n<li>The protein produced by this gene <strong>limits a step in the pigment pathway<\/strong>, leading to reddish-yellow (orange) coat colour.<\/li>\n<li>In <strong>male cats<\/strong> (with one X chromosome), the presence of the orange mutation <strong>activates Arhgap36<\/strong>, leading to orange fur. In <strong>female cats<\/strong> (with two X chromosomes), a process called <strong>X-chromosome inactivation<\/strong> creates <strong>mosaic coat patterns<\/strong> like tortoiseshell or calico.<\/li>\n<li><strong>Relevance to Human Health: <\/strong>ARHGAP36 has also been implicated in <strong>human conditions<\/strong> such as <strong>Skin cancer and <\/strong><strong>Baldness (hair loss). <\/strong>The gene&#8217;s involvement in these conditions shows its <strong>conserved biological importance across species<\/strong> and opens up avenues for <strong>comparative biomedical research<\/strong>.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>News: Two independent studies by Stanford University (USA) and Kyushu University (Japan) have identified the ARHGAP36 gene as the reason behind the orange coat colour in ginger cats. The discovery ends a century-long mystery in feline genetics. ARHGAP36 gene About ARHGAP36 gene\u00a0 The ARHGAP36 gene (Rho GTPase Activating Protein 36) encodes a regulatory protein that&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/arhgap36-gene\/\">Continue reading <span class=\"screen-reader-text\">ARHGAP36 gene<\/span><\/a><\/p>\n","protected":false},"author":10366,"featured_media":338638,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1566,1738,12039],"tags":[11872,10596],"class_list":["post-338300","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-daily-factly-articles","category-science-and-technology-daily-factly-articles","category-knolls","tag-9pm-daily-factly","tag-economic-times","entry"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/05\/ARHGAP36-gene.png?fit=1280%2C850&ssl=1","views":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/338300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10366"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=338300"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/338300\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media\/338638"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=338300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=338300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=338300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}