{"id":350413,"date":"2025-11-21T15:46:40","date_gmt":"2025-11-21T10:16:40","guid":{"rendered":"https:\/\/forumias.com\/blog\/?p=350413"},"modified":"2025-11-21T15:49:33","modified_gmt":"2025-11-21T10:19:33","slug":"birsa-101","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/birsa-101\/","title":{"rendered":"BIRSA 101"},"content":{"rendered":"<p><strong>News:<\/strong> India launched India&#8217;s first indigenous &#8220;CRISPR&#8221; based gene therapy for Sickle Cell Disease.<\/p>\n<h2>About BIRSA 101<\/h2>\n<figure id=\"attachment_350423\" aria-describedby=\"caption-attachment-350423\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"wp-image-350423\" src=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/11\/Source-Genetic-Education-300x201.jpg?resize=400%2C268&#038;ssl=1\" alt=\"BIRSA 101\" width=\"400\" height=\"268\" srcset=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/11\/Source-Genetic-Education.jpg?resize=300%2C201&amp;ssl=1 300w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/11\/Source-Genetic-Education.jpg?resize=1024%2C687&amp;ssl=1 1024w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/11\/Source-Genetic-Education.jpg?resize=768%2C515&amp;ssl=1 768w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2025\/11\/Source-Genetic-Education.jpg?w=1303&amp;ssl=1 1303w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><figcaption id=\"caption-attachment-350423\" class=\"wp-caption-text\">Source &#8211; Genetic Education<\/figcaption><\/figure>\n<ul>\n<li style=\"text-align: justify\">BIRSA 101 is India&#8217;s <strong>first indigenous CRISPR-based gene therapy.<\/strong><\/li>\n<li style=\"text-align: justify\"><strong>Aim:<\/strong> It is developed specifically for treating <strong>Sickle Cell Disease<\/strong>, a condition that heavily affects India\u2019s tribal population.<\/li>\n<li style=\"text-align: justify\"><strong>Named after:<\/strong> The therapy is named <strong>BIRSA 101<\/strong> in honour of <strong>Bhagwan Birsa Munda<\/strong>, a revered tribal freedom fighter, whose <strong>150th birth anniversary<\/strong> was recently celebrated.<\/li>\n<li style=\"text-align: justify\"><strong>Developed at:\u00a0 CSIR\u2013Institute of Genomics &amp; Integrative Biology (IGIB)<\/strong>, showcasing India\u2019s scientific capability in advanced therapeutics.<\/li>\n<li style=\"text-align: justify\"><strong>Technology used:<\/strong> It uses CRISPR technology that functions like <strong>\u201cprecise genetic surgery,\u201d<\/strong> capable of correcting the mutation responsible for <strong>Sickle Cell Disease<\/strong>.\n<ul>\n<li style=\"text-align: justify\">It has potential applications for treating <strong>several other hereditary disorders<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align: justify\"><strong>Affordable:<\/strong> The therapy is designed to be <strong>affordable<\/strong>, in contrast to global gene therapies that cost <strong>\u20b920\u201325 crore<\/strong> <strong>(over 3 million dollars).<\/strong><\/li>\n<li style=\"text-align: justify\">A formal technology transfer agreement was signed between <strong>CSIR-IGIB<\/strong> and the <strong>Serum Institute of India (SIIPL)<\/strong> to scale up and manufacture BIRSA 101.\n<ul>\n<li style=\"text-align: justify\">This partnership ensures <strong>affordability, scalability, and real-world clinical deployment<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Significance:<\/strong> Since Sickle Cell Disease disproportionately affects tribal populations in central and eastern India, BIRSA 101 holds <strong>special national importance<\/strong> for improving tribal health outcomes.\n<ul>\n<li style=\"text-align: justify\">The launch of BIRSA 101 marks the beginning of India\u2019s <strong>decisive journey<\/strong> toward achieving a <strong>Sickle Cell\u2013Free India by 2047<\/strong>, aligning with the Prime Minister\u2019s national mission.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>News: India launched India&#8217;s first indigenous &#8220;CRISPR&#8221; based gene therapy for Sickle Cell Disease. About BIRSA 101 BIRSA 101 is India&#8217;s first indigenous CRISPR-based gene therapy. Aim: It is developed specifically for treating Sickle Cell Disease, a condition that heavily affects India\u2019s tribal population. Named after: The therapy is named BIRSA 101 in honour of&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/birsa-101\/\">Continue reading <span class=\"screen-reader-text\">BIRSA 101<\/span><\/a><\/p>\n","protected":false},"author":10366,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1566,956,1738,12039],"tags":[11872],"class_list":["post-350413","post","type-post","status-publish","format-standard","hentry","category-daily-factly-articles","category-schemes-and-programs","category-science-and-technology-daily-factly-articles","category-knolls","tag-9pm-daily-factly","entry"],"jetpack_featured_media_url":"","views":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/350413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10366"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=350413"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/350413\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=350413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=350413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=350413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}