{"id":368144,"date":"2026-07-24T16:37:30","date_gmt":"2026-07-24T11:07:30","guid":{"rendered":"https:\/\/forumias.com\/blog\/?p=368144"},"modified":"2026-07-24T16:37:30","modified_gmt":"2026-07-24T11:07:30","slug":"lipfendra","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/lipfendra\/","title":{"rendered":"Lipfendra"},"content":{"rendered":"<div class=\"content-box-green\">\n<p><b>News: <\/b><span style=\"font-weight: 400;\">The FDA has approved the first once-daily oral PCSK9 inhibitor, to lower LDL cholesterol in adults with high cholesterol and certain inherited cholesterol disorders.<\/span><\/p>\n<\/div>\n<h2 class=\"red-h2-box\"><b>About Lipfendra<\/b><\/h2>\n<figure id=\"attachment_368161\" aria-describedby=\"caption-attachment-368161\" style=\"width: 396px\" class=\"wp-caption aligncenter\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\" wp-image-368161\" src=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/07\/Source-IE-4.jpg?resize=396%2C211&#038;ssl=1\" alt=\"Lipfendra\" width=\"396\" height=\"211\" srcset=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/07\/Source-IE-4.jpg?resize=300%2C160&amp;ssl=1 300w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/07\/Source-IE-4.jpg?resize=768%2C410&amp;ssl=1 768w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/07\/Source-IE-4.jpg?w=911&amp;ssl=1 911w\" sizes=\"auto, (max-width: 396px) 100vw, 396px\" \/><figcaption id=\"caption-attachment-368161\" class=\"wp-caption-text\">Source &#8211; IE<\/figcaption><\/figure>\n<ul>\n<li style=\"font-weight: 400;\">\u00a0<strong>Lipfendra<\/strong> is a <strong>once-daily oral tablet<\/strong> and is notable as the<strong> first oral medication to block PCSK9<\/strong>, a target previously addressed primarily through injectable therapies.\n<ul>\n<li><strong>Note:<\/strong> <strong>PCSK9 is <\/strong>a <strong>protein<\/strong> that <strong>reduces the liver\u2019s ability to clear LDL<\/strong> or <strong>bad cholesterol<\/strong> from the blood.<\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\"><b>Who it&#8217;s for:<\/b><span style=\"font-weight: 400;\"> It is <strong>prescribed for adults with high cholesterol,<\/strong> including those with a genetic condition called<strong> heterozygous familial hypercholesterolemia (HeFH).<\/strong><\/span><\/li>\n<li style=\"font-weight: 400;\"><b>How it works:<\/b><span style=\"font-weight: 400;\"> It works by <strong>blocking the action of a specific protein in the body<\/strong> called <strong>PCSK9.<\/strong><\/span>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Normally, t<strong>he PCSK9 protein makes it harder for your liver<\/strong> to remove low-density lipoprotein (LDL), or &#8220;bad&#8221; cholesterol, from your blood.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">By blocking this protein, <strong>Lipfendra (enlicitide) allows your liver to remove more LDL<\/strong> cholesterol from your bloodstream.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">As a result of this process,<strong> the medication helps to lower your overall cholesterol levels.<\/strong><\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\"><b>How it&#8217;s used:<\/b><span style=\"font-weight: 400;\"> It is taken <strong>once per day by mouth<\/strong> and<strong> should be used alongside a healthy diet and regular exercise.<\/strong><\/span><\/li>\n<li>It is<strong> indicated in patients whose LDL cholesterol cannot be reduced sufficiently by lifestyle measures<\/strong> and standard drugs alone or in whom the cardiovascular risk is high<\/li>\n<li style=\"font-weight: 400;\"><b>Common Side Effects in HeFH:<\/b><span style=\"font-weight: 400;\"> For people with genetic high cholesterol (HeFH), the most common side effects are diarrhea and dizziness.<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>News: The FDA has approved the first once-daily oral PCSK9 inhibitor, to lower LDL cholesterol in adults with high cholesterol and certain inherited cholesterol disorders. About Lipfendra \u00a0Lipfendra is a once-daily oral tablet and is notable as the first oral medication to block PCSK9, a target previously addressed primarily through injectable therapies. Note: PCSK9 is&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/lipfendra\/\">Continue reading <span class=\"screen-reader-text\">Lipfendra<\/span><\/a><\/p>\n","protected":false},"author":10366,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1566,1738,12039],"tags":[11872,10500],"class_list":["post-368144","post","type-post","status-publish","format-standard","hentry","category-daily-factly-articles","category-science-and-technology-daily-factly-articles","category-knolls","tag-9pm-daily-factly","tag-indian-express","entry"],"jetpack_featured_media_url":"","views":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/368144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10366"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=368144"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/368144\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=368144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=368144"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=368144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}