{"id":369859,"date":"2026-08-19T16:10:13","date_gmt":"2026-08-19T10:40:13","guid":{"rendered":"https:\/\/forumias.com\/blog\/?p=369859"},"modified":"2026-08-19T16:10:13","modified_gmt":"2026-08-19T10:40:13","slug":"bad-cholesterol","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/bad-cholesterol\/","title":{"rendered":"Bad Cholesterol"},"content":{"rendered":"<div class=\"content-box-green\">\n<p><strong>News:<\/strong> A new experimental gene-editing therapy, VERVE-102, permanently targets the PCSK9 gene to achieve long-term reduction in LDL cholesterol.<\/p>\n<\/div>\n<h2 class=\"red-h2-box\">About Bad Cholesterol<\/h2>\n<figure id=\"attachment_369863\" aria-describedby=\"caption-attachment-369863\" style=\"width: 572px\" class=\"wp-caption aligncenter\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\" wp-image-369863\" src=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/08\/Source-IE-2.jpg?resize=572%2C328&#038;ssl=1\" alt=\"Bad Cholesterol\" width=\"572\" height=\"328\" srcset=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/08\/Source-IE-2.jpg?resize=300%2C172&amp;ssl=1 300w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/08\/Source-IE-2.jpg?resize=768%2C440&amp;ssl=1 768w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/08\/Source-IE-2.jpg?w=858&amp;ssl=1 858w\" sizes=\"auto, (max-width: 572px) 100vw, 572px\" \/><figcaption id=\"caption-attachment-369863\" class=\"wp-caption-text\">Source &#8211; IE<\/figcaption><\/figure>\n<ul>\n<li><strong>Cholesterol:<\/strong> It is a <strong>waxy, fat-like substance found in all body cells<\/strong>.\n<ul>\n<li>The <strong>body needs<\/strong> some cholesterol to<strong> make hormones, vitamin D, and substances that help digest food.<\/strong><\/li>\n<li><strong>Sources:<\/strong> The <strong>liver makes cholesterol.<\/strong>\n<ul>\n<li>It is also <strong>found in animal-source foods<\/strong> such as meat, dairy products, and egg yolks.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Types of Cholesterol:<\/strong> The main types are <strong>HDL (High-Density Lipoprotein), LDL (Low-Density Lipoprotein), and VLDL (Very Low-Density Lipoprotein).<\/strong>\n<ul>\n<li>They are <strong>lipoproteins<\/strong>, which are <strong>combinations of fat (lipid) and protein<\/strong> that <strong>carry substances through the blood.<\/strong>\n<ul>\n<li data-start=\"268\" data-end=\"403\"><strong>HDL:<\/strong> It is <strong>called good cholesterol<\/strong> because it <strong>carries cholesterol from other parts of the body back to the liver for removal.<\/strong><\/li>\n<li data-start=\"404\" data-end=\"518\"><strong>LDL:<\/strong> It is called <strong>bad cholesterol<\/strong> because <strong>high levels can cause cholesterol to build up in the arteries.<\/strong><\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>VLDL<\/strong>: It mainly <strong>carries triglycerides<\/strong> and also <strong>contributes to plaque buildup in the arteries.<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Impacts of Bad Cholesterol:<\/strong>\n<ul>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Plaque formation:<\/strong> <strong>Excess LD<\/strong>L combines with other substances to <strong>form plaque in the arteries<\/strong>, causing them to <strong>harden and narrow.<\/strong><\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Cardiovascular risk:<\/strong> Narrowed or blocked arteries can <strong>reduce blood flow and increase the risk of heart attacks and strokes.<\/strong><\/li>\n<\/ul>\n<\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Factors Influencing Accumulation of Bad Cholesterol:<\/strong>\n<ul>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Unhealthy diet:<\/strong> Eating too much saturated fat can raise LDL cholesterol.<\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Physical inactivity:<\/strong> Lack of exercise can lower HDL cholesterol.<\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Smoking:<\/strong> Smoking lowers HDL and raises LDL cholesterol.<\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Excessive alcohol:<\/strong> Drinking too much alcohol can raise total cholesterol levels.<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Existing Treatments:<\/strong>\n<ul>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Statins:<\/strong> These are <strong>medicines used to lower LDL cholesterol,<\/strong> but their effect <strong>needs to be maintained through continued treatment.<\/strong><\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Ezetimibe:<\/strong> It is a medicine used to lower cholesterol.<\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>PCSK9 inhibitors:<\/strong> These <strong>medicines block the PCSK9 protein,<\/strong> which helps reduce LDL cholesterol and cardiovascular events.<\/li>\n<li data-start=\"519\" data-end=\"622\" data-is-last-node=\"\"><strong>Inclisiran:<\/strong> It is an <strong>injectable prescription medicine<\/strong> used as an existing <strong>treatment for lowering cholesterol.<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 class=\"red-h2-box\">About VERVE-102<\/h2>\n<ul>\n<li><strong>VERVE-102<\/strong>\u00a0is an <strong>in<\/strong> <strong>vivo gene-editing therapy<\/strong> that <strong>permanently changes gene function in liver cells.<\/strong><\/li>\n<li><strong>Aim:<\/strong> It aims to <strong>permanently switch off the PCSK9 gene,<\/strong> <strong>reducing the liver&#8217;s ability to produce PCSK9.<\/strong>\n<ul>\n<li><strong>PCSK9 is a protein involved in regulating LDL cholesterol<\/strong> in the blood<\/li>\n<\/ul>\n<\/li>\n<li><strong>Single infusion:<\/strong> It is designed as a <strong>one-time intravenous treatment,<\/strong> unlike medicines that require continued treatment.<\/li>\n<li><strong>Limitation:<\/strong> Its ability to prevent heart attacks or strokes remains unproven, while its <strong>long-term effects require further research.<\/strong><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>News: A new experimental gene-editing therapy, VERVE-102, permanently targets the PCSK9 gene to achieve long-term reduction in LDL cholesterol. About Bad Cholesterol Cholesterol: It is a waxy, fat-like substance found in all body cells. The body needs some cholesterol to make hormones, vitamin D, and substances that help digest food. Sources: The liver makes cholesterol.&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/bad-cholesterol\/\">Continue reading <span class=\"screen-reader-text\">Bad Cholesterol<\/span><\/a><\/p>\n","protected":false},"author":10401,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1566,1738,12039],"tags":[11872],"class_list":["post-369859","post","type-post","status-publish","format-standard","hentry","category-daily-factly-articles","category-science-and-technology-daily-factly-articles","category-knolls","tag-9pm-daily-factly","entry"],"jetpack_featured_media_url":"","views":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/369859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10401"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=369859"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/369859\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=369859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=369859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=369859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}