{"id":370873,"date":"2026-09-02T16:13:29","date_gmt":"2026-09-02T10:43:29","guid":{"rendered":"https:\/\/forumias.com\/blog\/?p=370873"},"modified":"2026-09-02T16:13:29","modified_gmt":"2026-09-02T10:43:29","slug":"cold-allodynia","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/cold-allodynia\/","title":{"rendered":"Cold Allodynia"},"content":{"rendered":"<div class=\"content-box-green\">\n<p><strong>News:<\/strong> Researchers from IISc Bengaluru and TCG-CREST identified a brain circuit linked to chemotherapy-induced cold allodynia in mice.<\/p>\n<\/div>\n<h2 class=\"red-h2-box\">About Cold Allodynia<\/h2>\n<figure id=\"attachment_370881\" aria-describedby=\"caption-attachment-370881\" style=\"width: 367px\" class=\"wp-caption aligncenter\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\" wp-image-370881\" src=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/09\/Source-The-Jackson-Lab.jpg?resize=367%2C242&#038;ssl=1\" alt=\"Cold Allodynia\" width=\"367\" height=\"242\" srcset=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/09\/Source-The-Jackson-Lab.jpg?resize=300%2C198&amp;ssl=1 300w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/09\/Source-The-Jackson-Lab.jpg?resize=768%2C506&amp;ssl=1 768w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/09\/Source-The-Jackson-Lab.jpg?w=777&amp;ssl=1 777w\" sizes=\"auto, (max-width: 367px) 100vw, 367px\" \/><figcaption id=\"caption-attachment-370881\" class=\"wp-caption-text\">Source &#8211; The Jackson Lab<\/figcaption><\/figure>\n<ul>\n<li><strong>Cold allodynia<\/strong>\u00a0is a <strong>nerve-related condition<\/strong> in which <strong>even normal or mild cold temperatures can cause pain or distress.<\/strong><\/li>\n<li><strong>Symptoms:<\/strong> It may cause <strong>sharp, burning or shooting pain, tingling, and pins-and-needles sensations.<\/strong>\n<ul>\n<li>It can also cause increased <strong>sensitivity to mild cold, including air conditioning, drafts, cold water, or cold objects.<\/strong><\/li>\n<\/ul>\n<\/li>\n<li><strong>Common Cause:<\/strong>\n<ul>\n<li><strong>Chemotherapy:<\/strong> <strong>Oxaliplatin<\/strong>, a commonly used <strong>platinum-based chemotherapy drug<\/strong>, is a <strong>major cause <\/strong>of cold allodynia.<\/li>\n<li><strong>Diabetes:<\/strong> Diabetes can <strong>damage peripheral nerves<\/strong> and may lead to cold allodynia.<\/li>\n<li><strong>Viral infections:<\/strong> Viral infections <strong>can irritate nerves<\/strong> and cause persistent neuropathic pain.<\/li>\n<li><strong>Injuries:<\/strong> Physical injuries <strong>can damage or irritate sensory nerves<\/strong> and may trigger nerve pain.<\/li>\n<li><strong>Nutritional deficiencies:<\/strong> <strong>Lack of B vitamins,<\/strong> particularly <strong>Vitamin B12,<\/strong> can <strong>impair nerve health<\/strong> and may contribute to cold allodynia.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Diagnosis:<\/strong> Healthcare providers <strong>assess the symptoms<\/strong> and may <strong>test responses to temperature, light touch, and vibration,<\/strong> along with laboratory tests or nerve studies when required.<\/li>\n<li><strong>Treatment:<\/strong>\n<ul>\n<li><strong>Medicines:<\/strong> <strong>Pregabalin, gabapentin, and duloxetine<\/strong> target nerve pain pathways.\n<ul>\n<li><strong>Lidocaine and capsaicin creams<\/strong> may help <strong>desensitize skin receptors<\/strong>, while <strong>Nonsteroidal anti-inflammatory drugs (NSAIDs) may help when inflammation is also present.<\/strong><\/li>\n<\/ul>\n<\/li>\n<li><strong>Lifestyle measures:<\/strong> Keeping the feet warm, <strong>avoiding cold triggers,<\/strong> <strong>gentle exercise,<\/strong> <strong>adequate B vitamins<\/strong>, and <strong>stress management<\/strong> may provide relief.<\/li>\n<li><strong>Alternative therapies:<\/strong> <strong>Acupuncture<\/strong> may help some people by modulating pain signals, while <strong>Transcutaneous Electrical Nerve Stimulation (TENS) uses mild electrical currents to block pain pathways.<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>News: Researchers from IISc Bengaluru and TCG-CREST identified a brain circuit linked to chemotherapy-induced cold allodynia in mice. About Cold Allodynia Cold allodynia\u00a0is a nerve-related condition in which even normal or mild cold temperatures can cause pain or distress. Symptoms: It may cause sharp, burning or shooting pain, tingling, and pins-and-needles sensations. It can also&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/cold-allodynia\/\">Continue reading <span class=\"screen-reader-text\">Cold Allodynia<\/span><\/a><\/p>\n","protected":false},"author":10401,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1566,1738,12039],"tags":[11872],"class_list":["post-370873","post","type-post","status-publish","format-standard","hentry","category-daily-factly-articles","category-science-and-technology-daily-factly-articles","category-knolls","tag-9pm-daily-factly","entry"],"jetpack_featured_media_url":"","views":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/370873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10401"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=370873"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/370873\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=370873"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=370873"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=370873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}