{"id":372109,"date":"2026-09-18T17:40:57","date_gmt":"2026-09-18T12:10:57","guid":{"rendered":"https:\/\/forumias.com\/blog\/?p=372109"},"modified":"2026-09-18T17:40:57","modified_gmt":"2026-09-18T12:10:57","slug":"melanoma","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/melanoma\/","title":{"rendered":"Melanoma"},"content":{"rendered":"<div class=\"content-box-green\">\n<p><strong>News:<\/strong> In August 2026, intismeran, a personalised mRNA vaccine, showed reduced melanoma recurrence when combined with pembrolizumab.<\/p>\n<\/div>\n<h2 class=\"red-h2-box\">About Melanoma<\/h2>\n<figure id=\"attachment_372113\" aria-describedby=\"caption-attachment-372113\" style=\"width: 241px\" class=\"wp-caption aligncenter\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\" wp-image-372113\" src=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/09\/Source-Cleveland-Clinic-1.jpg?resize=241%2C574&#038;ssl=1\" alt=\"Melanoma\" width=\"241\" height=\"574\" srcset=\"https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/09\/Source-Cleveland-Clinic-1.jpg?resize=126%2C300&amp;ssl=1 126w, https:\/\/i0.wp.com\/forumias.com\/blog\/wp-content\/uploads\/2026\/09\/Source-Cleveland-Clinic-1.jpg?w=344&amp;ssl=1 344w\" sizes=\"auto, (max-width: 241px) 100vw, 241px\" \/><figcaption id=\"caption-attachment-372113\" class=\"wp-caption-text\">Source &#8211; Cleveland Clinic<\/figcaption><\/figure>\n<ul>\n<li><strong>Melanoma<\/strong> is a <strong>type of skin cancer.<\/strong><\/li>\n<li>It <strong>develops from melanocytes,<\/strong> the <strong>cells that produce melanin.<\/strong><\/li>\n<li>It usually <strong>develops on sun-exposed skin<\/strong>, including the arms, back, face and legs.<\/li>\n<li>In India, <strong>it commonly occurs on the soles of the feet or beneath<\/strong> the <strong>nails and is called acral lentiginous melanoma.<\/strong><\/li>\n<li>Mucosal melanoma <strong>starts in the mucous membranes<\/strong> and is highly aggressive, with few early warning signs.<\/li>\n<li><strong>Causes:<\/strong>\n<ul>\n<li><strong>UV Exposure<\/strong>: Most melanomas are <strong>caused by exposure to ultraviolet (UV) light<\/strong> from sunlight or tanning lamps and beds.<\/li>\n<li><strong>Unclear Cause:<\/strong> The exact cause of all melanomas is <strong>not clear.<\/strong><\/li>\n<\/ul>\n<\/li>\n<li><strong>Symptoms:<\/strong>\n<ul>\n<li><strong>Mole Changes:<\/strong> A <strong>change in an existing mole<\/strong> can be a warning sign.<\/li>\n<li><strong>New Growth:<\/strong> A <strong>new pigmented or unusual-looking growth<\/strong> may <strong>develop on the skin.<\/strong><\/li>\n<li><strong>Persistent Lesions:<\/strong> Any <strong>pigmented lesion that changes or persists needs investigation.<\/strong><\/li>\n<\/ul>\n<\/li>\n<li><strong>Treatment:<\/strong>\n<ul>\n<li><strong>Surgery:<\/strong> In early stages, surgery has a high probability of curing melanoma.<\/li>\n<li><strong>Lymphadenectomy:<\/strong> If melanoma has spread, <strong>nearby lymph nodes may need to be removed.<\/strong><\/li>\n<li><strong>Metastasectomy:<\/strong> It is <strong>used to remove small melanoma growths<\/strong> from organs.<\/li>\n<li><strong>Immunotherapy:<\/strong> Immune-checkpoint blockade using <strong>therapies targeting CTLA<\/strong>&#8211;<strong>4<\/strong> (Cytotoxic T-Lymphocyte-Associated Protein4)<strong> and PD-1<\/strong> (Programmed Cell Death Protein 1) can help the immune system attack tumours.<\/li>\n<li><strong>Precision medicine:<\/strong> Next-generation sequencing (<strong>NGS<\/strong>) can <strong>identify tumour mutations,<\/strong> including <strong>BRAF pathway mutations, to guide targeted treatment.<\/strong><\/li>\n<li><strong>TIL therapy:<\/strong> <strong>Tumour-infiltrating lymphocytes (TILs) are taken from the tumour,<\/strong> expanded in the laboratory and reinfused in larger numbers.<\/li>\n<li><strong>Personalised mRNA vaccine:<\/strong> In August 2026, <strong>intismeran with pembrolizumab significantly reduced<\/strong> recurrence after surgery, <strong>although survival data remain pending.<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>News: In August 2026, intismeran, a personalised mRNA vaccine, showed reduced melanoma recurrence when combined with pembrolizumab. About Melanoma Melanoma is a type of skin cancer. It develops from melanocytes, the cells that produce melanin. It usually develops on sun-exposed skin, including the arms, back, face and legs. In India, it commonly occurs on the&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/melanoma\/\">Continue reading <span class=\"screen-reader-text\">Melanoma<\/span><\/a><\/p>\n","protected":false},"author":10401,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[1566,1738,12039],"tags":[11872],"class_list":["post-372109","post","type-post","status-publish","format-standard","hentry","category-daily-factly-articles","category-science-and-technology-daily-factly-articles","category-knolls","tag-9pm-daily-factly","entry"],"jetpack_featured_media_url":"","views":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/372109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/10401"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=372109"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/372109\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=372109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=372109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=372109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}