{"id":84800,"date":"2019-08-17T14:37:02","date_gmt":"2019-08-17T09:07:02","guid":{"rendered":"http:\/\/factly.forumias.com\/?p=9242"},"modified":"2019-08-17T14:37:02","modified_gmt":"2019-08-17T09:07:02","slug":"fda-approves-new-oral-three-drug-regimen-for-extensively-drug-resistant-tb","status":"publish","type":"post","link":"https:\/\/forumias.com\/blog\/fda-approves-new-oral-three-drug-regimen-for-extensively-drug-resistant-tb\/","title":{"rendered":"FDA approves new oral three-drug regimen for extensively drug-resistant TB"},"content":{"rendered":"\n<ol class=\"wp-block-list\"><li>The US Food and Drug Administration (FDA) has\napproved new oral three-drug regimen for the extensively-drug resistant\ntuberculosis (XDR-TB).<\/li><li>The treatment involves Pretomanid tablets in\ncombination with bedaquiline and linezolid, collectively referred to as the\nBPaL regimen. It has an efficacy rate of 90%. Pretomanid was developed by TB\nAlliance, a not-for-profit organisation.<\/li><li>Tuberculosis (TB) is an infectious airborne\nbacterial disease caused by Mycobacterium tuberculosis. It most commonly\naffects the lungs but can also damage other parts of the body. <\/li><li>There are two TB-related conditions: a) Latent\nTB &#8211; the bacteria remain in the body in an inactive state. They cause no symptoms\nand are not contagious, but they can become active and b) Active TB &#8211; the\nbacteria do cause symptoms and can be transmitted to others.<\/li><li>When TB infection becomes resistant to the first\nline of treatment \u2014 isoniazid and rifampicin, it is called Multi-drug resistant\nTB (MDR-TB). Two major reasons for prevalence of MDR TB are: a) mismanagement\nof TB treatment (incomplete and incorrect treatment) and b) person to person\ntransmission. <\/li><li>Extensively-drug resistant tuberculosis (XDR-TB)\nis a more serious form of MDR TB. It happens when the infection becomes\nresistant even to the second-line treatment. It has a mortality rate of 60%.<\/li><li>According to 2018 WHO TB update, there are 1,\n14,237 MDR-TB patients globally, of which more than 8,000 are XDR-TB. India has\n26,966 MDR-TB patients, the highest in the world, while there are 2,130 XDR-TB\npatients.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>The US Food and Drug Administration (FDA) has approved new oral three-drug regimen for the extensively-drug resistant tuberculosis (XDR-TB). The treatment involves Pretomanid tablets in combination with bedaquiline and linezolid, collectively referred to as the BPaL regimen. It has an efficacy rate of 90%. Pretomanid was developed by TB Alliance, a not-for-profit organisation. Tuberculosis (TB)&hellip; <a class=\"more-link\" href=\"https:\/\/forumias.com\/blog\/fda-approves-new-oral-three-drug-regimen-for-extensively-drug-resistant-tb\/\">Continue reading <span class=\"screen-reader-text\">FDA approves new oral three-drug regimen for extensively drug-resistant TB<\/span><\/a><\/p>\n","protected":false},"author":61,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"categories":[956],"tags":[1727],"class_list":["post-84800","post","type-post","status-publish","format-standard","hentry","category-schemes-and-programs","tag-tuberculosis","entry"],"jetpack_featured_media_url":"","views":{"total":0,"cached_at":"","cached_date":1704946625},"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/84800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/users\/61"}],"replies":[{"embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/comments?post=84800"}],"version-history":[{"count":0,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/posts\/84800\/revisions"}],"wp:attachment":[{"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/media?parent=84800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/categories?post=84800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/forumias.com\/blog\/wp-json\/wp\/v2\/tags?post=84800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}