Doubt Clearance Thread: UPSC 2021
"When in doubt, observe and ask questions. When certain, observe at length and ask many more questions."
Created this thread as a one stop solution for all members so that all the doubts wherein any conceptual clarification is required can be solved here.
Conquer,
Guys, if a question asks that which act abolished East India Company, what should be the answer? As I read somewhere that 1858 act abolished it as an administrative body while as a company it was abolished somewhere around 1870.
I found in some places it is just written that East India Company was abolished through 1858 Act.
How does DNA vaccine work for COVID?
DNA vaccine uses a gene (the gene that is responsible for the spike protein of COVID) from the virus and once it enters the nucleus it is transcribed into mRNA and then translated into the spike protein. Now our bodies will create antibodies to that protein. In mRNA that first step of transcribing into mRNA is skipped.
mehuifs,HeNeArKr
How does DNA vaccine work for COVID?DNA vaccine uses a gene (the gene that is responsible for the spike protein of COVID) from the virus and once it enters the nucleus it is transcribed into mRNA and then translated into the spike protein. Now our bodies will create antibodies to that protein. In mRNA that first step of transcribing into mRNA is skipped.
But Corona virus is a RNA virus and not a DNA virus. Then how come DNA is made from RNA?
mRNA vaccine could be understood but not DNA. If I am worng or I am missing something then pls tell.
How does DNA vaccine work for COVID?DNA vaccine uses a gene (the gene that is responsible for the spike protein of COVID) from the virus and once it enters the nucleus it is transcribed into mRNA and then translated into the spike protein. Now our bodies will create antibodies to that protein. In mRNA that first step of transcribing into mRNA is skipped.
Just for some extra info: I thought that DNA vaccine is adding an extra step so how is it better than mRNA vaccine. Here's what I found:-
1)Dna is more stable than RNA so can be stored as room temp.
2) Dna vaccines are cheaper.
Disadvantages:-
there are some concerns as DNA's enter the nucleus of cells before forming mRna, so this may affect the cell DNA.
How does DNA vaccine work for COVID?DNA vaccine uses a gene (the gene that is responsible for the spike protein of COVID) from the virus and once it enters the nucleus it is transcribed into mRNA and then translated into the spike protein. Now our bodies will create antibodies to that protein. In mRNA that first step of transcribing into mRNA is skipped.
But Corona virus is a RNA virus and not a DNA virus. Then how come DNA is made from RNA?
mRNA vaccine could be understood but not DNA. If I am worng or I am missing something then pls tell.
Background Info:
Dna->is a piece of genetic info.
Spike protein->It's the part of coronavirus which latches to cells.
mRNA->used for sending the info to the Ribosomes which synthesizes the spike protein. (Because DNA ki bhasha ribosome ko nhi aati.)
Application:
So, in this vaccine, we are just sending the genetic information, not the actual virus. Now we can send the genetic info in rna or DNA form doesn't matter. Dna enters our nucleus forms the mrna which goes to the ribosomes which makes the spike protein, which in turns activates our immune system and creates antibodies.
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