How the Genome sequencing works? 

Firstly, the RNA of the virus sample is converted to DNA. It is cut into short fragments. Several copies of each fragment are made. 

Secondly, these fragments are loaded into a sequencer machine. The machine ‘reads’ the order of nucleotides of each of those several segments. The nucleotides are designated English alphabets A, T, C, G in a certain order. 

Thirdly, these ‘reads’ of several individual small segments are then fed into computer software. The software puts all those ‘reads’ together to form one complete genome or a whole genome sequence of nucleotides. This completes sequencing. 

Finally, the genome, which has been sequenced, is assigned a lineage through other web-based programmes. These lineages help one determine what variant it is, whether it matches with the lineage of nationally or internationally existing variants of the virus or a new variant has come up.