Diethylene Glycol (DEG)/Ethylene Glycol (EG) and Leptospirosis

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News: The Union Health Ministry recently confirmed that cough syrups linked to the recent deaths of children in Madhya Pradesh and Rajasthan did not contain contaminants.

About Diethylene Glycol (DEG)

Diethylene Glycol. DEG. Structural Chemical Formula and 3d Model of ...
Source: dreamstime.com
  • It is an organic chemical that is mainly used as a chemical intermediate. 
  • Appearance: It is a clear, colourless, odourless and stable oily liquid.
  • Group: It belongs to the ether and alcohol group.
  • Chemical FormulaC₄H₁₀O₃
  • Production Methods: Diethylene glycol is produced commercially as a by-product of ethylene glycol production.
    • It can also be produced directly through a reaction between ethylene glycol and ethylene oxide.
  • Characteristics: It is slightly viscous, noncorrosive and nonvolatile.
    • Diethylene glycol is miscible with water, ethers, lower aliphatic alcohols, aldehydes and ketones. 
    • It is partially soluble in benzene, carbon tetrachloride, monobenzene, orthodichlorobenzene and toluene.
    • It dissolves many dyes, resins, oils, nitrocellulose and many organic substances.
  • Uses: It is used in textile lubricants, cutting oils, dry cleaning soap, printing inks, steam-set inks, and nongrain wood stains.
    • Solvent: In the textile industry diethylene glycol is used as a conditioning agent for wool, rayon, and cotton. As a solvent for dyes it makes a valuable assistant in dyeing and printing.
    • Humectant: The high hygroscopicity of diethylene glycol makes it an efficient softening agent for tobacco, paper, synthetic sponges, glues and casein.
    • Diethylene glycol is especially useful in the dehydration of natural gas.

About Leptospirosis

LEPTOSPIROSIS
Source: mfsa.govmu.org
About 
  • Leptospirosis is an infectious bacterial disease caused by Leptospira species.
  • It affects both humans and animals (a zoonotic disease).
  • It is common in tropical and subtropical regions, especially during rainy and flood seasons.
Caused byLeptospira interrogans, a spiral-shaped bacterium.
Mode of Transmission
  • It spread through water, soil, or food contaminated with urine of infected animals (rats, cattle, dogs, pigs, etc.).
  • Infection occurs when the bacteria enter the body through cuts or abrasions on the skin, mucous membranes (eyes, mouth, nose) and drinking or swimming in contaminated water. 
Incubation PeriodUsually 2 to 30 days, most commonly around 7–14 days.
Symptoms
  • In mild cases: High fever, chills, Headache and severe muscle pain (especially calf muscles), Nausea, vomiting, and diarrhoea, Red eyes (conjunctival suffusion) and Skin rash.
  • In severe cases (Weil’s disease): Jaundice (yellowing of skin and eyes), Kidney and liver failure, bleeding (especially from lungs or nose) and Meningitis or encephalitis in some cases.
High-Risk Groups
  • Farmers and agricultural workers
  • Sewer and sanitation workers
  • Veterinarians and slaughterhouse workers
  • Children playing in floodwater
  • People in flood-prone or poorly sanitized areas
Treatment
  • Early antibiotic therapy is essential. Common antibiotics: Doxycycline, Penicillin, or Azithromycin.
  • Supportive care for complications (hydration, kidney/liver monitoring).
Prevention
  • Avoid swimming or wading in potentially contaminated water.
  • Wear protective clothing, boots, and gloves during farming or animal handling.
  • Control rodent population around homes and workplaces.
  • Maintain proper sanitation and dispose of waste properly.
  • Vaccination of animals (where available).
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