Q. Consider the following statements regarding Messenger RNA (mRNA) vaccines:
1.They are capable of eliciting both innate and adaptive immune responses.
2.They utilize a cell-free process for production, enabling rapid development and large-scale manufacturing.
3.mRNA vaccines possess higher inherent stability and thermotolerance compared to conventional inactivated virus vaccines.
Which of the statements given above are correct?
Answer: A
Notes:
Explanation:
- Statement 1 and 2 are correct: mRNA vaccines work by providing the genetic code for cells to produce an antigen, triggering a robust immune response (1). Because they are produced via chemical synthesis rather than in cell cultures, they allow for very fast production cycles (2).
- Statement 3 is incorrect: A major drawback of mRNA vaccines is their instability. They are highly sensitive to temperature and typically require ultra-cold chain storage (e.g., -70°C for Pfizer) to prevent the mRNA from degrading.
