Stargardt disease

News– Researchers from Switzerland have announced the development of a gene-editing technique that may potentially aid in the treatment of Stargardt disease.

About Stargardt Disease

• It is a rare inherited genetic disorder that leads to progressive vision loss, especially in children and young adults.
• Cause: The disease is caused by mutations in the ABCA4 gene, which disrupts the body’s ability to process Vitamin A properly. This leads to the accumulation of lipofuscin, a fatty substance that builds up on the macula—the central part of the retina responsible for sharp, central vision.
• Bilateral: Stargardt disease typically affects both eyes (bilateral), resulting in the gradual loss of central visual acuity in both eyes.
• No Cure: There is currently no cure or effective treatment for Stargardt disease, though research continues to explore potential therapies.